Currently, scientists have used several methods of extracting sericin contained in silk fiber. For example, the traditional thermal method, ultrasonic and microwave (ultra-high frequency - UHF rays) methods. When these methods are compared, the effectiveness of the microwave method is proven. Optimal conditions were selected for each method. We have conducted studies on the extraction of sericin from silk fiber using physical effects such as microwaves and ultrasound. Based on research, we tried to find the most acceptable conditions and methods.