The article examines the role of the cluster approach in the integration of structures in the agro-industrial complex in the production of raw cotton, processing of fiber and obtaining from it competitive final products for the internal and foreign markets. There are also considered features of application of a cluster method in formation of integrated in agro-industrial complex in processing of raw cotton and receiving from it competitive ready-made products for domestic and foreign markets. Drawbacks of low clustering in agro-industrial complex are revealed.