The article examines the theoretical and methodological foundations for the formation of meso-level housing infrastructure as a key component of the system of integrated territorial development. The role of housing infrastructure in integrating demographic, spatial, and economic factors of regional sustainable growth is substantiated. It is shown that the housing sector determines the spatial structure of settlement, influences migration processes, and shapes the quality of life of the population. Based on 2024–2025 statistical data, a comparative analysis of territorial differences in Uzbekistan’s housing stock at the meso level is conducted. The methodological principles of integrated planning are outlined, and recommendations are proposed for optimizing housing infrastructure in the regions.