The research based on several years of screening, strains resistant to NaCl and Na2SO4 salts (up to 200 mM) were selected from the cotton rhizosphere, it is identified that the strains of the Pseudomonas and Bacillus strains are classified as Pseudomonas stutzeri SKB-308, Bacillus subtilis SKB-309, and Bacillus megaterium SKB-310, as well as it is identified that under stress conditions (pH -9) they separate Indolyl acetic acid (IAA)19.4 ± 0.79; 20.7 ± 1.01; 17.74 ± 0.85 mg / l respectively, and it is identified that stamps of pseudomonas stutzeri SKB-308 synthesis 1-bromine-2-phthalimidetane compound with strong antagonistic activity against phytopathogens. On the basis of these bio preparations it is developed Zamin-M, as well as data on the effectiveness of this bio preparation on potato cultivation on degraded soils was analyzed. Studies have shown that, under the influence of the bio preparation, potato yield increased by 1.2 t/ha in Agrab variety and by 3.1 t / ha in Tuyimli variety.