The article discusses issues related to improving the reliability and accuracy of railway transport by minimizing the impact of human error. Based on an analysis of statistical data on occupational injuries and train safety violations in the Republic of Uzbekistan, it is shown that a significant proportion of incidents are caused by the actions of personnel performing critical technological operations. The need to move from predominantly technical safety measures to comprehensive management of human-machine systems is justified. The main causes of human error are identified and ways to minimize them at the design and implementation stages of railway transport technological processes are determined. The implementation of the proposed approaches contributes to improving traffic safety and the reliability of the railway system.