Examination of 32 children with atopic dermatitis, complicated by staphylococcal infection. Revealed violations of B-cell, humoral immunity and phagocytic activity of neutrophils. The revealed violations of immunological parameters in children suffering from atopic dermatitis complicated by staphylococcal infection are the basis for the appointment of immunomodulators as part of complex therapy aimed at stimulating the B-cell and humoral immunity, as well as the phagocytic activity of neutrophils.