The article is dedicated to the typological-comparative analyses of the twentieth century of American and Uzbek realistic novels —“Arrowsmith” and “The Three Roots”. Comparative literature is specialized in identifying common and unique features of national literatures. There are some similarities in the artistic creation of the novelists like Sinclair Lewis and Pirimkul Kodirov. Lewis was the first American writer who got the Nobel prize for literature. As for P. Kadirov, he made an immense contribution in the development of Uzbek prose. The article analyses and explains the common and diverse features of the two novels.