In the article formation of aminoalcohols and aminocompounds by Mannich reaction from acetylenic alcohols and phenylacetylene and also biological activity of halogenated derivatives of the synthesized aminocompounds have been inves -tigated. Acetylenic alcohols were synthesized by the reaction A.E. Favorsky and phenylacetylene was obtained from styrene. The influence of various factors (tem -perature, catalyst, time and nature of solvents) on the yield of aminoalcohols was studied. A theoretical analysis of the mechanism of formation of acetylenic aminoalcohols is given. The physico-chemical properties of the synthesized aminoalco-hols and their yields were determined. The chemical structure of aminoalcohols has been confirmed by IR and PMR spectrums. The biological activity of compo -unds synthesized by chlorination and bromination of aminocompounds has been investigated.