In this study, the synthesis of mixed-ligand coordination compounds of manganese (II) ion with indomethacin ligand and amides (formamide, acetamide, nicotinamide), as well as their physicochemical properties, was investigated. The complexes were obtained in solution by reacting manganese (II) chloride tetrahydrate (MnCl2·4H2O) and indomethacin (C19H16ClNO4) in specified molar ratios within a water–ethanol mixture. The resulting compounds were analyzed using elemental analysis, infrared (IR) spectroscopy, ultraviolet–visible (UV-Vis) spectroscopy, powder X-ray diffraction (PXRD), and thermogravimetric analysis (TGA). The results demonstrated that indomethacin coordinates to the metal center through carboxylate groups and that the complexes possess a stable structure. The findings of this research indicate that the mixed-ligand manganese complexes with indomethacin and amides may hold significant potential for future applications as therapeutic agents in pharmaceutical chemistry.