This article presents the synthesis and physicochemical characterization of a novel coordination compound formed from zinc nitrate and ketorolac. The compound [Zn(ket)2](NO3)2·2H2O was synthesized in a water–ethanol mixture under pH conditions of 5.5–6 and precipitated as white crystals. The synthesized compound was analyzed using IR spectroscopy, UV-Vis spectroscopy, and elemental analysis. The results confirmed the formation of Zn–O coordination bonds, with ketorolac acting as a ligand through its carboxyl group. The study emphasizes the significance of synthesizing new coordination compounds for applications in pharmaceutical and inorganic chemistry.