The results of the bromination reaction of the 2-arylquinoline alkaloid dubamine with N-bromosuccinimide and molecular bromine are presented in this paper. Dubamine was reacted with N-bromosuccinimide in DMF to obtain bromdubamine with a yield of 78.4%. However, when reacting with molecular bromine using glacial acetic acid as a solvent, hydrobromide of dubamine was obtained. The structure of the synthesized substances was proved by physical methods such as IR, 1H NMR, 13C NMR, and Mass.