In the era of the digital economy, fostering innovative activity in enterprises has become a crucial factor for sustainable economic growth. This article explores the prospects of digitalization and the development of open innovation ecosystems in Uzbekistan, drawing on local examples and international practices from countries such as Estonia and Singapore. The study emphasizes the role of digital platforms, AI analytics, smart production, and human capital development in enhancing productivity, reducing costs, and increasing competitiveness. Tables illustrate the expected effects of ecosystem integration and collaborative innovation. The findings highlight that digitalization is not merely a technological process, but a strategic approach ensuring long-term enterprise sustainability, resilience, and integration into global digital markets.