The article examines the main aspects of tourism development in the Republic of Karakalpakstan, one of the most unique territories of Uzbekistan. The key problems and prospects of the tourism industry of the region are studied, including natural, cultural and infrastructural resources that can become the basis for sustainable and multifaceted tourism. Particular attention is paid to the prospects and key aspects of the development of tourist routes and the creation of infrastructure on the basis of historical and archaeological sites of the Republic of Karakalpakstan, such as Tuprak-kala, Kizil-kala, Ayaz-kala, Guldirsin-kala and Kyryk Kyz-kala.