This article presents the results of an analysis of irrigation water consumption in the Khorezm region using geographic information systems (GIS) and remote sensing technologies. The study examines the main irrigation canals, irrigated areas, and water consumption dynamics in the Khorezm oasis, located in the lower reaches of the Amu Darya basin. Satellite data (Landsat 8/9, Sentinel-2), GIS modeling, and hydrological analysis methods were applied. The results indicate that water loss rates in the region range from 38 to 52%, equivalent to an annual average of 2.1–2.7 km³ of water wasted. In addition, 63% of croplands are affected by soil salinization to varying degrees. The article provides recommendations for optimizing the irrigation system and effectively managing water resources.