In order to create highly sensitive electrodes that detect a number of drugs during operation Ion selective electrodes (ISEs) were prepared based on
membranes containing heteropolymetallophosphate ionophores. A total of 12 drugs widely used in medical practice were selected for the preparation of heteropolymetallophosphate electrodes. The concentration of the component determined during the research in the range of 10-1 to 10-7 mol/l detection range and sensitivity of the developed electrodes studied. Based on the results of the research ISEs developed on the basis of drug-dodecomolybdophosphate acidcontaining ionophoresi ncluding dibazol and pyridoxine ISEs developed on the basis of drug dodecatungstophosphate ionophores have been proven to be highly sensitive to diprazine and bromhexine drugs.