The study investigated the effects of salinity level, soil profile depth, and seasonal conditions on the abundance of nitrogen-fixing microorganisms in irrigated takyr-meadow soils. The number of nitrogen fixers decreased consistently with increasing salinity and soil depth. The highest values were recorded in the 0-25 cm layer during summer. Under strong salinity, the reduction in nitrogen-fixing microorganisms reached 78.8-86.2%, while correlation coefficients ranged from r = 0.989 to 0.993.