This study evaluated the effects of mineral fertilizer rates on the leaf area index, grain yield, and economic efficiency of the “Daulet” sorghum cultivar. The highest leaf area index of 5.21 m²/m² was recorded with N240P140K120 kg/ha. However, the highest grain yield of 6.12 t/ha, net profit of 18 131 380 UZS/ha, and profitability of 108.12% were obtained with N200P120K100 kg/ha. Therefore, this fertilizer rate was identified as the most agronomically and economically efficient treatment.